BCMA Nanobody
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描述
BCMA Nanobody
靶点背景信息（Background）
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) is also known as B-cell maturation protein (BCMA), CD antigen CD269, which is a member of the TNF-receptor superfamily. TNFRSF17 contains one TNFR-Cys repeat. TNFRSF17 is expressed in mature B-cells, but not in T-cells or monocytes. TNFRSF17 is receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. TNFRSF17 promotes B-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 can activate NF-kappa-B and JNK.
纳米抗体信息（Nanobody）
Nanobodies targeting BCMA are derived from an alpaca immune library immunized against recombinant BCMA protein, and are expressed and prepared using a prokaryotic E. coli system.
